Kempf, Dale J.: search on Z-Library

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1

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Kempf, Dale J., Sham, Hing L., Marsh, Kennan C., Flentge, Charles A., Betebenner, David, Green, Brian E., McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E., Kati, Warren M.,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 189 KB

english, 1998

2

Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)

Hing L Sham, David A Betebenner, Thomas Herrin, Gondi Kumar, Ayda Saldivar, Sudthida Vasavanonda, Akhter Molla, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

3

Synthesis and structure–activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

Hing L. Sham, David A. Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

4

Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Pamela L. Donner, Qinghua Xie, John K. Pratt, Clarence J. Maring, Warren Kati, Wen Jiang, Yaya Liu, Gennadiy Koev, Sherie Masse, Debra Montgomery, Akhter Molla, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

5

X-ray crystallographic structure of ABT-378 (Lopinavir) bound to HIV-1 protease

Vincent Stoll, Wenying Qin, Kent D. Stewart, Clarissa Jakob, Chang Park, K. Walter, R.L. Simmer, Rosalind Helfrich, Dirk Bussiere, J. Kao, Dale Kempf, Hing L. Sham, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 246 KB

english, 2002

6

Selection of Multiple Human Immunodeficiency Virus Type 1 Variants that Encode Viral Proteases with Decreased Sensitivity to an Inhibitor of the Viral Protease

Andrew H. Kaplan, Scott F. Michael, Robert S. Wehbie, Mark F. Knigge, Deborah A. Paul, Lorraine Everitt, Dale J. Kempf, Daniel W. Norbeck, John W. Erickson and Ronald Swanstrom

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

7

Assembling Pharma Resources to Tackle Diseases of Underserved Populations

Kempf, Dale J., Marsh, Kennan C

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

Language:

english

File:

PDF, 249 KB

english, 2020

8

Structure-based, C2 symmetric inhibitors of HIV protease

Kempf, Dale J., Norbeck, Daniel W., Codacovi, LynnMarie, Wang, Xiu Chun, Kohlbrenner, William E., Wideburg, Norman E., Paul, Deborah A., Knigge, Mark F., Vasavanonda, Sudthida

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 398 KB

english, 1990

9

Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors

Xiaoqi Chen, Lin Li, Dale J. Kempf, Hing Sham, Norman E. Wideburg, Ayda Saldivar, Sudthida Vasavanonda, Kennan C. Marsh, Edith McDonald, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 313 KB

english, 1996

10

Synthesis and antiviral activity of P1′ arylsulfonamide azacyclic urea HIV protease inhibitors

Peggy P Huang, John T Randolph, Larry L Klein, Sudthida Vasavanonda, Tatyana Dekhtyar, Vincent S Stoll, Dale J Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 321 KB

english, 2004

11

Sequence and Phenotypic Analysis for Resistance Monitoring in Hepatitis C Virus Drug Development: Recommendations From the HCV DRAG

Ann D. Kwong, Isabel Najera, Jill Bechtel, Scott Bowden, Joseph Fitzgibbon, Patrick Harrington, Dale Kempf, Tara L. Kieffer, Diana Koletzki, George Kukolj, Sharlene Lim, Tami Pilot–Matias, Kai Lin, Ni

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 5.55 MB

english, 2011

12

Pseudo-symmetrical difluoroketones: Highly potent and specific inhibitors of HIV-1 protease

Hing L. Sham, David A. Betebenner, Norman Wideburg, Ayda C. Saldivar, William E. Kohlbrenner, Adrienne Craig-Kennard, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Clement, John E. Erickson, Jacob J.

Journal:

Year:

1993

Language:

english

File:

PDF, 380 KB

english, 1993

13

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine

Hidaka, Koushi, Kimura, Tooru, Sankaranarayanan, Rajesh, Wang, Jun, McDaniel, Keith F., Kempf, Dale J., Kameoka, Masanori, Adachi, Motoyasu, Kuroki, Ryota, Nguyen, Jeffrey-Tri, Hayashi, Yoshio, Kiso,

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 903 KB

english, 2018

14

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships

Hing L Sham, Chen Zhao, Leping Li, David A Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

15

Recent developments in HIV protease inhibitor therapy

Akhteruzzaman Molla, G Richard Granneman, Eugene Sun, Dale J Kempf

Journal:

Antiviral Research

Year:

1998

Language:

english

File:

PDF, 299 KB

english, 1998

16

Dipole-stabilized carbanions: evidence for a complex in the .alpha.'-lithiation of N,N-dimethyl-2,4,6-triisopropylbenzamide

Al-Aseer, Munther, Beak, Peter, Hay, David, Kempf, Dale J., Mills, Sander, Smith, Stanley G.

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 364 KB

english, 1983

17

Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5

Upadhyay, Anup K., Cyr, Matthew, Longenecker, Kenton, Tripathi, Rakesh, Sun, Chaohong, Kempf, Dale J.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2017

Language:

english

File:

PDF, 1.18 MB

english, 2017

18

[Methods in Enzymology] Retroviral proteases Volume 241 || [18] Design of symmetry-based, peptidomimetic inhibitors of human immunodeficiency virus protease

Year:

1994

Language:

english

File:

PDF, 1000 KB

english, 1994

19

Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease

Dale J. Kempf, Charles A. Flentge, Norman E. Wideburg, Ayda Saldivar, Sudthida Vasavanonda, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 225 KB

english, 1995

20

Oximinoarylsulfonamides as potent HIV protease inhibitors

Clinton M. Yeung, Larry L. Klein, Charles A. Flentge, John T. Randolph, Chen Zhao, MingHua Sun, Tatyana Dekhtyar, Vincent S. Stoll, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 185 KB

english, 2005

21

Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats

Yi Yang, Annette J. Dahly-Vernon, Eric A.G. Blomme, Jie Lai-Zhang, Dale J. Kempf, Kennan C. Marsh, Yvette A. Harrington, Steven H. Nye, Darin L. Evans, Richard J. Roman, Howard J. Jacob, Jeffrey F. Wa

Journal:

The Veterinary Journal

Year:

2010

Language:

english

File:

PDF, 769 KB

english, 2010

22

P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses

DeGoey, David A., Grampovnik, David J., Chen, Hui-Ju, Flosi, William J., Klein, Larry L., Dekhtyar, Tatyana, Stoll, Vincent, Mamo, Mulugeta, Molla, Akhteruzzaman, Kempf, Dale J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.68 MB

english, 2011

23

Remote lithiation of N-methallyl amides

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 251 KB

english, 1989

24

Novel Lopinavir Analogues Incorporating Non-aromatic P-1 Side Chains — Synthesis and Structure—Activity Relationships.

Hing L. Sham, Chen Zhao, Leping Li, David A. Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Year:

2003

File:

PDF, 147 KB

2003

25

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia

Jeffrey F. Waring, Rita Ciurlionis, Kennan Marsh, Larry L. Klein, David A. DeGoey, John T. Randolph, Brian Spear, Dale J. Kempf

Journal:

Archives of Toxicology

Year:

2010

Language:

english

File:

PDF, 635 KB

english, 2010

26

A C 2 Symmetry-Based HIV Protease Inhibitor, A77003, Irreversibly Inhibits Infectivity of HIV-1 In Vitro

KAGEYAMA, SEIJI, HOEKZEMA, DAVID T., MURAKAWA, YOHKO, KOJIMA, EIJI, SHIRASAKA, TAKUMA, KEMPF, DALE J., NORBECK, DANIEL W., ERICKSON, JOHN, MITSUYA, HIROAKI

Journal:

AIDS Research and Human Retroviruses

Year:

1994

Language:

english

File:

PDF, 946 KB

english, 1994

27

Corrigenda

Sham, Hing L., Wideburg, Norman E., Spanton, Stephen G., Kohlbrenner, William E., Betebenner, David A., Kempf, Dale J., Norbeck, Daniel W., Plattner, Jacob J., Erickson, John W., Shen, Gwo-Jenn, Wang,

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1991

Language:

english

File:

PDF, 71 KB

english, 1991

28

Stereochemical studies of lasalocid epimers. Ion-driven epimerizations.

W.Clark Still, Peter Hauck, Dale Kempf

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 241 KB

english, 1987

29

Synthesis of rigid, heterocyclic dipeptide analogs

Kempf, Dale J., Condon, Stephen L.

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 742 KB

english, 1990

30

The .beta.' lithiation of .alpha.,.beta.-unsaturated amides

Beak, Peter, Kempf, Dale J., Wilson, Kenneth D.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 1.61 MB

english, 1985

31

ChemInform Abstract: Synthesis and Structure—Activity Relationships of a Novel Series of HIV-1 Protease Inhibitors Encompassing ABT-378 (Lopinavir).

Hing L. Sham, David A. Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Year:

2002

Language:

english

File:

PDF, 32 KB

english, 2002

32

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Clarence J. Maring, Dale J. Kempf, Warren M. Kati, Vincent Stoll, Kent D. Stewart, Graeme Laver

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 308 KB

english, 2005

33

Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease

Hosur, Madhusoodan V., Bhat, T. Narayana, Kempf, Dale J., Baldwin, Eric T., Liu, Beishan, Gulnik, Sergei, Wideburg, Norman E., Norbeck, Daniel W., Appelt, Krzysztof, Erickson, John W.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 4.14 MB

english, 1994

34

A Rapid Fluorogenic Assay of HIV Protease Inhibitors

EDMUND MATAYOSHI, GARY WANG, GRANT KRAFFT, DALE KEMPF, LYNN CODACOVI, JOHN ERICKSON

Journal:

Annals of the New York Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 135 KB

english, 1990

35

The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir

Kempf, Dale J., Rode, Richard A., Xu, Yi, Sun, Eugene, Heath-Chiozzi, Margo E., Valdes, Joaquin, Japour, Anthony J., Danner, Sven, Boucher, Charles, Molla, Akhteruzzaman, Leonard, John M.

Journal:

Year:

1998

Language:

english

File:

PDF, 149 KB

english, 1998

36

Enantioselective Synthesis of Antiinfluenza Compound A-315675 (I).

David A. DeGoey, Hui-Ju Chen, William J. Flosi, David J. Grampovnik, Clinton M. Yeung, Larry L. Klein, Dale J. Kempf

Journal:

Year:

2002

File:

PDF, 27 KB

2002

37

Synthesis and Antiviral Activity of P1′ Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors.

Peggy P. Huang, John T. Randolph, Larry L. Klein, Sudthida Vasavanonda, Tatyana Dekhtyar, Vincent S. Stoll, Dale J. Kempf

Journal:

Year:

2004

File:

PDF, 23 KB

2004

38

Progress in the discovery of orally bioavailable inhibitors of HIV protease

Journal:

Perspectives in Drug Discovery and Design

Year:

1995

Language:

english

File:

PDF, 618 KB

english, 1995

39

Stereocontrolled synthesis of Ψ[CH=CH] dipeptide isosteres

DALE J. KEMPF, XIU CHUN WANG, STEPHEN G. SPANTON

Journal:

Chemical Biology & Drug Design

Year:

1991

Language:

english

File:

PDF, 477 KB

english, 1991

40

.beta.'-Lithiation of .alpha.,.beta.-unsaturated secondary amides

Beak, Peter, Kempf, Dale J.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 262 KB

english, 1980

41

Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostere

Sham, Hing L., Betebenner, David A., Zhao, Chen, Wideburg, Norman E., Saldivar, Ayda, Kempf, Dale J., Plattner, Jacob J., Norbeck, Daniel W.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1993

Language:

english

File:

PDF, 164 KB

english, 1993

42

Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans

Gondi N. Kumar, Venkata K. Jayanti, Marianne K. Johnson, John Uchic, Samuel Thomas, Ronald D. Lee, Brian A. Grabowski, Hing L. Sham, Dale J. Kempf, Jon F. Denissen, Kennan C. Marsh, Eugene Sun, Stanle

Journal:

Pharmaceutical Research

Year:

2004

Language:

english

File:

PDF, 121 KB

english, 2004

43

Renin inhibitors based on novel dipeptide analogs. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond

Kempf, Dale J., De Lara, Ed, Stein, Herman H., Cohen, Jerome, Plattner, Jacob J.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 871 KB

english, 1987

44

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm

Stephen Hanessian, Jianchio Wang, Debra Montgomery, Vincent Stoll, Kent D. Stewart, Warren Kati, Clarence Maring, Dale Kempf, Charles Hutchins, W.Graeme Laver

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 189 KB

english, 2002

45

Highly efficient synthesis of 2(S)-3(R,S)-2-amino-4,4-difluoro-1,6-diphenyl-3-hydroxyhexane — the key intermediate for a series of potent HIV proteinase inhibitors

Hing L. Sham, David A. Betebenner, Norman E. Wideburg, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Journal of Fluorine Chemistry

Year:

1995

Language:

english

File:

PDF, 332 KB

english, 1995

46

Relationship between Adherence and the Development of Resistance in Antiretroviral‐Naive, HIV‐1–Infected Patients Receiving Lopinavir/Ritonavir or Nelfinavir

King, Martin S., Brun, Scott C., Kempf, Dale J.

Journal:

The Journal of Infectious Diseases

Year:

2005

Language:

english

File:

PDF, 524 KB

english, 2005

47

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

A. Chris Krueger, Yibo Xu, Warren M. Kati, Dale J. Kempf, Clarence J. Maring, Keith F. McDaniel, Akhteruzzaman Molla, Debra Montgomery, William E. Kohlbrenner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 135 KB

english, 2008

48

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands

Xiaoqi Chen, Dale J. Kempf, Lin Li, Hing L. Sham, Sudthida Vasavanonda, Norman E. Wideburg, Ayda Saldivar, Kennan C. Marsh, Edith McDonald, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 176 KB

english, 2003

49

Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site

Rosenberg, Saul H., Dellaria, Joseph F., Kempf, Dale J., Hutchins, Charles W., Woods, Keith W., Maki, Robert G., De Lara, Ed, Spina, Kenneth P., Stein, Herman H.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.60 MB

english, 1990

50

Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Wang, Gary T., Chen, Yuanwei, Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Kati, Warren, Muchmore, Steve, Giranda, Vincent, Stewart, Kent, Sham, Hing, Kempf, Dale, Laver, W. Graeme

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 457 KB

english, 2001

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